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NU Researchers Synthesize Hypertension Drugs from Rice Husk and Corncob

The Renewable Energy Laboratory at Nazarbayev University, led by Professor Nurxat Nuraje, has developed an innovative technology in pharmaceutical synthesis. The method enables the transformation of agricultural waste into two essential medications¡ªprazosin and furosemide¡ªused to treat hypertension and edema. The process utilizes continuous flow reactors, marking a significant advance in sustainable drug production. This breakthrough has the potential to revolutionize the pharmaceutical industry by converting agricultural biowaste into active pharmaceutical ingredients (APIs).

27 Aug 2025
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The Renewable Energy Laboratory at Nazarbayev University, led by Professor Nurxat Nuraje, has developed an innovative technology in pharmaceutical synthesis.

The method enables the transformation of agricultural waste into two essential medications¡ªprazosin and furosemide¡ªused to treat hypertension and edema. The process utilizes continuous flow reactors, marking a significant advance in sustainable drug production. This breakthrough has the potential to revolutionize the pharmaceutical industry by converting agricultural biowaste into active pharmaceutical ingredients (APIs).

As a world-first achievement, the development demonstrates the successful integration of green chemistry principles with real industrial applicability. By harnessing the advantages of flow chemistry, the team has developed a sustainable, efficient, and scalable process that stands as a blueprint for future pharmaceutical manufacturing, placing Kazakhstan at the forefront of global pharmaceutical innovation.  This research may also be incorporated into new academic courses offered at the university.

The research team included senior researcher Minavar Shaimardan, assistant researcher Kyran Kassym, junior researcher Zhanat Azhikhanova, and doctoral students Harry Kwaku Megbenu and Makpal Rakhatkyzy. The team extends its sincere gratitude to external collaborators, Professors Alina M. Balu and Rafael Luque, for their invaluable support in realizing this achievement.